• Signed written Informed Consent Form

• Male or female, age ≥ 18 years old

• Histologically confirmed gastric adenocarcinoma, diagnosed as locally progressive according to the AJCC 8th ed, cTNM diagnosis of cT3-4aN1-3M0 and resectable lesion as assessed by the investigator

• No prior systemic therapy such as surgery, radiotherapy, or immunotherapy for the disease at hand

• Consent to radical surgical treatment and no contraindications to surgery as determined by the surgeon

• ECOG PS: 0-1 score

• Expected survival \> 6 months

• Adequate organ function, must meet the following laboratory specifications:

‣ 1 Absolute neutrophil count (ANC) ≥ 1.0x10\^9/L; 8.2 Platelets ≥ 80x10\^9/L; 8.3 Hemoglobin \> 7g/dL; 8.4 Total bilirubin ≤ 1.5 x upper limit of normal (ULN) (Total bilirubin \> 1.5 x ULN but direct bilirubin ≤ ULN are allowed to be enrolled); 8.5 AST, ALT ≤ 2.5×ULN; 8.6 Blood creatinine ≤ 1.5 x ULN or creatinine clearance ≥ 60 ml/min; 8.7 INR or PT ≤ 1.5 times ULN; 8.8 TSH within normal range (Enrollment allowed if baseline TSH is outside normal range but FT4 is within normal range); 8.9 Myocardial enzyme profile within normal range;

• Negative pregnancy test in women of childbearing age

⁃ Need to use contraception with an annual failure rate of less than 1% if there is a risk of conception